Tight Glucose Control versus Intermediate Glucose Control: A Quasi-Experimental Study

Moving beyond tight glucose control to safe effective glucose control

The impressive benefits related to the use of tight glucose control by intensive insulin therapy have not been reproduced until now in multicenter large-scale prospective randomized trials. Although the reasons for these failures are not entirely clear, we suggest the use of a stepwise approach - Safe, Effective Glucose Control - that will essentially target an intermediate blood glucose level....

Does tight glucose control enhance brain sensitivity to low glucose?

Tight Glucose Control Raised Mortality in ICU

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Tight glucose control: sweet or sour?

Introduction: The debate about the potential benefi ts of tight glucose control in intensive care patients has been ongoing since the exciting initial single-center study by Van den Berghe et al. [1], which demonstrated reduced mortality in patients managed according to a protocol aimed at maintaining blood glucose between 80 and 110 mg/dL compared with the then-standard goal of less than 215 m...

Glucose control in the ICU--how tight is too tight?

For the past decade, hospitals have focused on the inpatient management of hyperglycemia, particularly in the intensive care unit (ICU). Extensive observational data have shown a consistent, almost linear relationship between blood glucose levels in hospitalized patients and adverse clinical outcomes, even in patients without established diabetes.1 It has never been entirely clear, however, whe...